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September 17, 2010, the U.S. Food and Drug Administration (FDA) issued the information, said: on the pioglitazone (brand name: Viagra extension) the decade-long study found that long-term or high dose to the FDA there is the risk of bladder cancer .

Pioglitazone is used to treat type 2 diabetes, adult patients control blood sugar. Pioglitazone manufacturer Takeda has conducted this research and analysis, and the results submitted to the U.S. FDA. Overall, there is no direct data that the use of Pioglitazone and risk of bladder cancer had significant correlation. However, studies of time and dose of medication for in-depth analysis, the results showed that patients with long-term or heavy drug use increased risk of bladder cancer.

FDA has not yet pioglitazone risk of bladder cancer, a conclusion, related research continues. If there are new developments, FDA will update this security information. Authority proposes to present a doctor should be in accordance with the package insert for patients with pioglitazone, recommend that patients do not arbitrarily stop.

Summary of research data

Pioglitazone (Actos) in July 1999 approved in the U.S. market. In therapeutic doses, this drug use after an average glycated hemoglobin levels lower than 1.5% of placebo. Pioglitazone in pre-clinical animal studies, researchers found that rats receiving pioglitazone and clinical drug plasma concentration levels of blood concentration, it will suffer from bladder cancer. In addition, two 3-year clinical study (PROactive study and safety study of a liver) results indicated. Compared with the control group, receiving pioglitazone therapy in patients with a higher proportion of bladder cancer. At present these findings has been added to pioglitazone manual notes section.
To further determine the long-term risk of human bladder cancer drug, Takeda’s ongoing research.

Ai Extension of approval of imports in 2009, and is widely used in clinical, my company in Beijing, Guangzhou, Shanghai and other stores have sales, so need to remind the majority of customers and customer service staff, in the purchase or sale of this drug, be sure to remind Dr. Gu Kezai and under the guidance of pharmacists to use this medication, and do not over dose long-term use. Customers who are using this drug is also no need to panic, any drug will have side effects, but not everyone will be using the drugs have side effects, and just follow the instructions of doctors and pharmacists in the proper use of drugs is under the guidance can reduce the incidence of adverse reactions!

The main symptoms of bladder cancer is hematuria. Hematuria mostly caused by bleeding due to tumor rupture. Hematuria may be more or less, for a long time the naked eye can see, a little time just to see under the microscope in the urine red blood cells. Bladder cancer, hematuria gross hematuria is usually full, that the whole process of urination blood in urine have shown, the time will do more in the urine dark urine; it can be started urinating blood in urine and then turn clear, or the brighter start and then into the urine hematuria. Hematuria due to other diseases than the urine of bladder cancer has two characteristics: First, painless, that in the event of hematuria, the patient no pain and other symptoms, medical as painless hematuria. This is when the stones have hematuria more with renal, ureteral pain differs, too, with more than cystitis with hematuria due to urinary frequency, urgency, dysuria different. However, if the tumor necrosis, ulceration and infection, can frequent urination, urgency, dysuria and other urinary bladder irritation. The second is intermittent, that is, intermittent hematuria, can stop or reduce their own, two hematuria can be a few days or months intervals, or even six months, likely to cause hematuria has cured the illusion of improvement, thereby failing to timely treatment check.

Painless hematuria is the most important sign of bladder cancer, almost all patients with bladder cancer were asked to appear in this signal. If we can catch this signal, in time to check, you can achieve early detection, early treatment, and achieved good effect. If hematuria occurs only once or twice, the patient is not yet seriously, consciously because of fatigue or a cold caused a big problem, so that patients often mistaken for hematuria is self-healing, without further treatment, thereby losing the best time for treatment. The extension of the long-term use of Viagra patients can also choose to periodically check.

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